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You'll gain real-world insights into how economics impacts your daily life with this easy-to-follow online course. This crash course is based on the acclaimed textbook Economy, Society, and Public Policy by CORE Econ, tailored to help you grasp key concepts without feeling overwhelmed.

Whether you're new to economics or just want to deepen your understanding, this course covers the basics and connects them to today’s pressing issues—from inequality to public policy decisions.

Each week, you'll receive a reading guide that distills core principles, offers actionable takeaways, and explains how they affect the current world. While the full ebook enriches the experience, the guides alone provide a comprehensive understanding of fundamental economic ideas.

You’ll find this course especially useful and unique because…
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Do you believe that MPR is an important community resource?");})("#tfa_130-L > b:nth-of-type(1)")}}, C_940895_39_1_2_0:{ fn:function(log,nonce=''){return (function(x) { try{ var _vwo_sel = vwo_$("`); !vwo_$("head").find('#1740425171461').length && vwo_$('head').append(_vwo_sel);}catch(e) {console.error(e)} try{}catch(e) {console.error(e)} try{const getCurrentDate = (d = new Date()) => d.toISOString().split('T')[0]; function vwoCustomEvent (labelValue) { window.VWO = window.VWO || []; VWO.event = VWO.event || function () {VWO.push(["event"].concat([].slice.call(arguments)))}; VWO.event("customEvent", { "label": labelValue.toString() }); } class RadioButtonComponent { constructor (element) { this.radio = element.querySelector('input[type="radio"]'); this.label = element.querySelector('label'); } get value () { let value = this.radio.value; if (Number.isNaN(parseFloat(value))) return value; if (parseFloat(value) % 1 == 0) return parseInt(value); return parseFloat(value); } set value (newValue) { this.radio.value = newValue; } get text () { return this.label.textContent; } set text (newText) { if (this.label.querySelector('.form-required')) { const labelTextNode = [...this.label.childNodes].filter(({ nodeType }) => nodeType === Node.TEXT_NODE)[0]; labelTextNode.nodeValue = newText; } else { this.label.textContent = newText; } } get checked () { return this.radio.checked; } set checked (bool) { this.click(), bool === true && this.radio.checked === true; } click () { this.label.click(); } select () { this.click(); } addEventListener (eventType, callbackFunction) { switch (eventType) { case 'click': this.label.addEventListener(eventType, callbackFunction); case 'change': default: this.radio.addEventListener(eventType, callbackFunction); } } } class TextFieldComponent { constructor (element) { this.input = element.querySelector('input[type="text"]'); this.label = element.querySelector('label'); } get value () { return this.input.value; } set value (newValue) { this.input.dispatchEvent(new Event('focus')); this.input.value = newValue; this.input.dispatchEvent(new Event('keyup')); this.input.dispatchEvent(new Event('change')); this.input.dispatchEvent(new Event('blur')); } get text () { return this.input.placeholder; } set text (newText) { this.input.placeholder = newText; } addEventListener (eventType, callbackFunction) { this.input.addEventListener(eventType, callbackFunction); } } class GiftArrayButton extends RadioButtonComponent { constructor (element) { super(element); } get amount () { return this.value; } set amount (newAmount) { if (Number.isNaN(parseInt(newAmount)) || parseInt(newAmount) <= 0) throw new Error("New amount must be a valid number greater than 0."); newAmount = parseInt(newAmount); this.text = '$' + newAmount; this.value = newAmount; } } class GiftArrayOtherAmount extends TextFieldComponent { constructor (element) { super(element); } get amount () { return parseFloat(this.value); } set amount (newAmount) { if (Number.isNaN(parseInt(newAmount)) || parseInt(newAmount) <= 0) throw new Error("New amount must be a valid number greater than 0."); newAmount = parseFloat(newAmount); this.value = newAmount; this.input.dispatchEvent(new Event('updateSummary')); } } class GiftArray extends Array { constructor (items) { if (!Array.isArray(items) && items.length === 0) { throw new Error("GiftArray: Arugment 1 is not an instance of Array with a length greater than 0:" + items.join(', ')); } if (items.every((item) => item instanceof GiftArrayButton || item instanceof GiftArrayOtherAmount)) { if (items.find((item) => item instanceof GiftArrayOtherAmount)) { let temp = items.find((item) => item instanceof GiftArrayOtherAmount); items = items.filter((item) => item instanceof GiftArrayButton); items.push(temp); } } else if (items.every((item) => item instanceof HTMLElement)) { items = items.map((item) => item.matches(".webform-component-textfield") ? new GiftArrayOtherAmount(item) : new GiftArrayButton(item)); } else { throw new Error("GiftArray: Arugment 1 is not of type HTMLElement, HTMLElement[], or GiftArrayButton|GiftArrayButton[]:" + items.join(', ')); } super(...items); this.Buttons = items.filter((item) => item instanceof GiftArrayButton); this.OtherAmountInput = items.find((item) => item instanceof GiftArrayOtherAmount); } get amount () { const activeButton = this.Buttons.find((item) => item.checked); if (activeButton.value === "other") { const otherButton = activeButton; if (!otherButton) { throw new Error("GiftArray.amount: Other Button was not defined."); } otherButton.click(); return this.OtherAmountInput.value; } else { return activeButton.value; } } set amount (newAmount) { if (Number.isNaN(parseInt(newAmount)) || parseInt(newAmount) <= 0) throw new Error("New amount must be a valid number greater than 0."); newAmount = parseFloat(newAmount); const matchingButton = this.find((item) => item.value === newAmount); if (matchingButton) { matchingButton.click(); } else { const otherButton = this.Buttons.find((item) => item.value === "other"); otherButton.click(); this.OtherAmountInput.amount = newAmount; } } addEventListeners (eventType, callbackFunction, filter = undefined) { if (filter && typeof filter === 'function') { const filteredItems = this.filter((item) => filter.call(this, item)); filteredItems.forEach((item) => item.addEventListener(eventType, callbackFunction)); } else if (filter && typeof filter === 'string') { if (filter.match(/buttons/gmi)) this.Buttons.forEach((item) => item.addEventListener(eventType, callbackFunction)); if (filter.match(/other/gmi)) this.OtherAmountInput.addEventListener(eventType, callbackFunction); } else { this.forEach((item) => item.addEventListener(eventType, callbackFunction)); } } } class FrequencyButton extends RadioButtonComponent { constructor (element) { super(element); } get frequency () { return this.text.match(/Monthly/gmi) ? "Monthly" : "One-Time"; } set freqency (newAmount) { if (Number.isNaN(parseInt(newAmount)) || parseInt(newAmount) <= 0) throw new Error("New amount must be a valid number greater than 0."); newAmount = parseInt(newAmount); this.text = '$' + newAmount; this.value = newAmount; } } class FrequencyArray extends Array { constructor (items) { if (!Array.isArray(items) && items.length === 0) { throw new Error("FrequencyArray: Arugment 1 is not an instance of Array with a length greater than 0:" + items.join(', ')); } /*if (items.every((item) => item instanceof GiftArrayButton || item instanceof GiftArrayOtherAmount)) { if (items.find((item) => item instanceof GiftArrayOtherAmount)) { let temp = items.find((item) => item instanceof GiftArrayOtherAmount); items = items.filter((item) => item instanceof GiftArrayButton); items.push(temp); } } else*/ if (items.every((item) => item instanceof HTMLElement)) { items = items.map((item) => item.matches(".webform-component-textfield") ? new GiftArrayOtherAmount(item) : new GiftArrayButton(item)); } else { throw new Error("FrequencyArray: Arugment 1 is not of type HTMLElement or HTMLElement[]:" + items.join(', ')); } super(...items); this.Buttons = items.filter((item) => item instanceof GiftArrayButton); } get frequency () { const activeButton = this.Buttons.find((item) => item.checked); if (activeButton.value === "recurs") return "monthly"; if (activeButton.value === "NO_RECURR") return "one-time"; return activeButton.value; } set frequency (newFrequency) { const reNewFrequencyValue = new RegExp(newFrequency, 'gmi'); const matchingButton = this.find((item) => item.value.match(reNewFrequencyValue) || item.text.match(reNewFrequencyValue)); matchingButton.click(); } get recurring () { return this.frequency === "monthly" ? true : false; } set recurring (bool) { this.frequency = bool === true ? "monthly" : "one-time"; } addEventListeners (eventType, callbackFunction, filter = undefined) { if (filter && typeof filter === 'function') { const filteredItems = this.filter((item) => filter.call(this, item)); filteredItems.forEach((item) => item.addEventListener(eventType, callbackFunction)); } else if (filter && typeof filter === 'string') { if (filter.match(/buttons/gmi)) this.Buttons.forEach((item) => item.addEventListener(eventType, callbackFunction)); if (filter.match(/other/gmi)) this.OtherAmountInput.addEventListener(eventType, callbackFunction); } else { this.forEach((item) => item.addEventListener(eventType, callbackFunction)); } } } // const lockedProperty = { writable: false, configurable: false, enumerable: true }; function DonationFormAPI (elements, options = {}) { const defaultOptions = { min: 1.00, max: 999999.99, makeTabbed: false, fakeSubmit: true, overrideGiftArrayValues: false, }; options = { ...defaultOptions, ...options }; // const { frequencyRadios, submitButton, root } = elements; const [ amountRadiosOnetime, amountRadiosMonthly ] = elements.amountRadios; const oneTimeOtherAmountWrapper = amountRadiosOnetime.find((div) => !div.matches('.webform-component-textfield') || div.querySelector('input[type="text"]')); const oneTimeRadioButtons = amountRadiosOnetime.filter((div) => div !== oneTimeOtherAmountWrapper); const monthlyOtherAmountWrapper = amountRadiosMonthly.find((div) => !div.matches('.webform-component-textfield') || div.querySelector('input[type="text"]')); const monthlyRadioButtons = amountRadiosMonthly.filter((div) => div !== monthlyOtherAmountWrapper); const debug = { log: (...args) => window.NA.DonationForm.DEBUG_MODE && console.log(...args), info: (...args) => window.NA.DonationForm.DEBUG_MODE && console.log(...args), warn: (...args) => window.NA.DonationForm.DEBUG_MODE && console.log(...args), error: (...args) => window.NA.DonationForm.DEBUG_MODE && console.log(...args), }; // const api = new Object(); Object.defineProperty(api, 'root', { value: root, writable: false, configurable: true, enumerable: true, }); Object.defineProperties(api, { 'FORM_MINIMUM': { value: options.min || 0, ...lockedProperty }, 'FORM_MAXIMUM': { value: options.max || Infinity, ...lockedProperty }, }); Object.defineProperties(api, { GiftArrays: { value: { "one-time": new GiftArray([ ...oneTimeRadioButtons, oneTimeOtherAmountWrapper ]), "monthly": new GiftArray([ ...monthlyRadioButtons, monthlyOtherAmountWrapper ]), }, writable: false, configurable: true, enumerable: true, }, Frequencies: { value: new FrequencyArray(frequencyRadios), writable: false, configurable: true, enumerable: true, }, SubmitButton: { value: submitButton, writable: false, configurable: false, enumerable: true, } }); Object.defineProperties(api, { 'getFrequency': { value: async function () { if (!this || this === null) throw new Error("validate: Unable to read API context."); return new Promise((resolve, reject) => { try { resolve(this.Frequencies.frequency); } catch (error) { reject(error); } }); }, ...lockedProperty }, 'setFrequency': { value: async function (frequency) { if (!this || this === null) throw new Error("validate: Unable to read API context."); return new Promise(async (resolve, reject) => { try { this.Frequencies.frequency = frequency; if (await this.getFrequency() === frequency) resolve(frequency); } catch (error) { reject(error); } }); }, ...lockedProperty }, 'getAmount': { value: async function (frequency = undefined) { if (!this || this === null) throw new Error("validate: Unable to read API context."); return new Promise(async (resolve, reject) => { try { frequency = frequency || await this.getFrequency(); if (frequency && this.GiftArrays.hasOwnProperty(frequency)) { const activeGiftArray = this.GiftArrays[frequency]; resolve(activeGiftArray.amount); } else { throw new Error("getAmount: Invalid frequency: " + frequency); } } catch (error) { reject(error); } }); }, ...lockedProperty }, 'setAmount': { value: async function (amount, frequency = undefined) { if (!this || this === null) throw new Error("validate: Unable to read API context."); return new Promise(async (resolve, reject) => { try { const currentFrequency = await this.getFrequency(); if (!frequency) { frequency = currentFrequency; } else if (frequency !== currentFrequency) { frequency = await this.setFrequency(frequency); } if (frequency && this.GiftArrays.hasOwnProperty(frequency)) { const activeGiftArray = this.GiftArrays[frequency]; activeGiftArray.amount = amount; } else { throw new Error("setAmount: Invalid frequency: " + frequency); } if (await this.getAmount() === amount) resolve(amount); } catch (error) { reject(error); } }); }, ...lockedProperty }, 'getRecurring': { value: async function () { if (!this || this === null) throw new Error("validate: Unable to read API context."); return new Promise((resolve, reject) => { try { resolve(this.Frequencies.recurring); } catch (error) { reject(error); } }); }, ...lockedProperty }, 'setRecurring': { value: async function (bool) { if (!this || this === null) throw new Error("validate: Unable to read API context."); return new Promise(async (resolve, reject) => { try { this.Frequencies.frequency = bool ? true : false; if (await this.getRecurring() === bool) resolve(bool); } catch (error) { reject(error); } }); }, ...lockedProperty }, freqency: { get () { return this.getFrequency() }, set (value) { this.setFrequency(value) }, enumerable: true, configurable: true, }, amount: { get () { return this.getAmount() }, set (value) { this.setAmount(value) }, enumerable: true, configurable: true, }, recurring: { get () { return this.getRecurring() }, set (value) { this.setRecurring(value) }, enumerable: true, configurable: true, }, }); Object.defineProperties(api, { 'submit': { value: async function (condition = this.validate||function(){return true}) { //this.hooks['onBeforeSubmit'].forEach((callback) => callback.call(this)); let result; const isAsyncFunction = (func) => func.constructor.name === "AsyncFunction"; if (Array.isArray(condition)) { if (condition.every((c) => typeof c === 'function' && isAsyncFunction(c))) { result = await Promise.all(condition.map(async (c) => await c.call(this))); } else if (condition.every((c) => typeof c === 'function')) { result = condition.every((c) => c.call(this)); } else if (condition.every((c) => c === true || c === false)) { result = condition.every((c) => c); } } else if (typeof condition === 'function' && isAsyncFunction(condition)) { result = await condition.call(this); } else if (typeof condition === 'function') { result = condition.call(this); } else if (condition === true || condition === false) { result = condition; } else { console.error("Unknown error."); debugger; } // if (result === true) { if (window.NA.DonationForm.hasOwnProperty("DEBUG_MODE") && window.NA.DonationForm["DEBUG_MODE"] == true) return console.log("Submit aborted (debug mode is enabled)."); this.SubmitButton.click(), this.hooks['onSubmit'].forEach((callback) => callback.call(this)); //this.hooks['onAfterSubmit'].forEach((callback) => callback.call(this)); } else { return console.log("Submit failed (conditions did not evaluate to true)."); } }, ...lockedProperty }, 'interceptSubmit': { value: function (handleInterceptedSubmit = () => { return new Promise((resolve) => resolve(undefined)) }) { try { window.NA.DonationForm.SubmitButtonCopy = window.NA.DonationForm.SubmitButtonCopy || createNewSubmitButton(window.NA.DonationForm.SubmitButton, { cloneOriginal: false, hideOriginal: true, observeOriginal: false }); window.NA.DonationForm.SubmitButtonCopy.addEventListener('click', async (event) => { event.preventDefault(), event.stopPropagation(); const shouldFormSubmit = await handleInterceptedSubmit.call(this, event); if (shouldFormSubmit) { console.info("Submit allowed by initial interceptSubmit callback function resulting in a truthy evaluation."); const formIsValid = await window.NA.DonationForm.validate(); if (!formIsValid) { // if submit allowed but there are known errors in the form console.warn("Form has known errors. Attempting to submit to show errors then retrying."); console.log("Submitting..."); window.NA.DonationForm.submit(true); // submit anyway to trigger the error to be shown window.NA.DonationForm.SubmitButton.style.setProperty("display", "none"), debug.info("SubmitButton hidden."), // hide the original submit button again window.NA.DonationForm.SubmitButtonCopy.style.setProperty("display", "none"), debug.info("SubmitButtonCopy hidden."); // hide the copy of the submit button again window.NA.DonationForm.SubmitButtonCopy.style.removeProperty("display"), debug.info("SubmitButtonCopy unhidden."); // show the copy of the submit button } else { console.log("Submitting..."); window.NA.DonationForm.submit(true); } } else { console.log("Submit prevented."); console.info("Next submit will be allowed."); window.NA.DonationForm.SubmitButton.style.removeProperty("display"), debug.info("SubmitButton unhidden."); // show the original submit button so that if something goes wrong the user can still click the submit button window.NA.DonationForm.SubmitButtonCopy.style.setProperty("display", "none"), debug.info("SubmitButtonCopy hidden."); // hide the copy of the submit button that intercepts submit attempts so that there aren't two buttons } }); console.log("Submit intercept added.\nButton:", window.NA.DonationForm.SubmitButtonCopy); } catch (error) { console.error("Failed to add submit intercept:", error); } }, ...lockedProperty }, 'validate': { value: async function (root = undefined) { if (!this || this === null) throw new Error("validate: Unable to read API context."); root = root || this.root; const flattenArray = (array) => array.reduce((flat, toFlatten) => flat.concat(Array.isArray(toFlatten) ? flattenArray(toFlatten) : toFlatten), []); try { const freqency = await this.getFrequency(), amount = await this.getAmount(); if (!freqency || !amount) return false; if (amount < this.FORM_MINIMUM || amount > this.FORM_MAXIMUM) return console.error("validate:", "Gift amount is invalid:", amount), false; let requiredFields = Array.from(root.querySelectorAll('label:has(.form-required)')) .map((label) => document.getElementById(label.htmlFor) || (label.nextElementSibling || label.previousElementSibling)) .filter((_) => !!_) // remove blanks .filter((field) => { if (field.name && field.name.includes('[payment_information]')) return false; return true; }) .map((field) => { if (field.matches("div")) return [...field.querySelectorAll('input')]; return field; }) requiredFields = flattenArray(requiredFields); const valid = requiredFields.every((input) => { const type = input.tagName.toLowerCase() === 'select' ? 'select' : input.type; const { name, value, id } = input; //console.log(type, name, value); if (name === 'submitted[payment_information][payment_fields][credit][card_number]') { if (value && value.length === 16) return true; return console.error("validate:", name+':', "CC is invalid."), false; } if (name === 'submitted[leadership_circle]') return true; if (name === 'submitted[donation][other_amount]' || name === 'submitted[donation][recurring_other_amount]') if (amount) return true; switch (type) { case 'email': const emailRegex = /^[a-zA-Z0-9._%+-]+@[a-zA-Z0-9.-]+\.[a-zA-Z]{2,}$/; if (!emailRegex.test(value)) return console.error("validate:", name+':', "Email address is invalid.\n", input, value), false; return true; case 'tel': if (!value || value.length < 10) return console.error("validate:", name+':', "Phone number is invalid.\n", input, value), false; return true; case 'select': case 'radio': case 'text': if (!value || value.length === 0) return console.error("validate:", name+':', "Field is invalid.\n", input, value), false; return true; default: debug.log("default"); return true; } /*if (!value || value.length === 0) return false;*/ }); return valid; } catch (error) { console.error(error); return false; } }, ...lockedProperty }, //'makeTabbed': { value: function(){} }, 'DonationInterrupter': { value: { init: initDonationInterrupter.bind(api) }, enumerable: true, configurable: true, writable: true, } }); initHooks(api, ['onFrequencyChange', 'onAmountChange', 'onTrySubmit', 'onSubmit']); api.Frequencies.addEventListeners('change', (event) => { if (event.target.checked) { api.hooks['onFrequencyChange'].forEach((callback) => { callback.call(api, event.target.value); }); } }); Object.entries(api.GiftArrays).forEach(([ key, GiftArray ]) => { GiftArray.addEventListeners('change', (event) => { if (event.target.checked) { api.hooks['onAmountChange'].forEach((callback) => { callback.call(api, event.target.value); }); } }); }); api.SubmitButton.addEventListener('click', (event) => { api.hooks['onTrySubmit'].forEach((callback) => callback.call(api, event)); }); api.root.addEventListener('submit', (event) => { api.hooks['onSubmit'].forEach((callback) => callback.call(api, event)); }); if (options.makeTabbed) api.makeTabbed(); /*if (options.fakeSubmit) window.NA.DonationForm.SubmitButtonCopy = window.NA.DonationForm.SubmitButtonCopy || createNewSubmitButton(window.NA.DonationForm.SubmitButton, { cloneOriginal: false, hideOriginal: true, observeOriginal: false });*/ return api; } function createNewSubmitButton (originalSubmitButton = window.NA.DonationForm.SubmitButton, options = {}) { const defaultOptions = { cloneOriginal: true, hideOriginal: true, observeOriginal: true, }; options = { ...defaultOptions, ...options }; const newSubmitButton = document.createElement('button'); //newSubmitButton.id = "submit-button-copy"; newSubmitButton.classList.add("btn"); newSubmitButton.textContent = originalSubmitButton.value; originalSubmitButton.after(newSubmitButton); options.hideOriginal && originalSubmitButton.style.setProperty("display", "none"); return newSubmitButton; } function initHooks (api, hookNames = []) { const hooks = Object.fromEntries(hookNames.map((hookName) => ([hookName, new Array()]))); Object.defineProperty(api, 'hooks', { value: hooks, ...lockedProperty }); } function initDonationInterrupter (options = {}) { const getExpId = () => { let experiments = window._vwo_exp; experiments = Object.entries(window._vwo_exp); let id = experiments.find(([id, data]) => { const name = data.name; return name.match(/Donation Interrupter/); })[1]?.id; return id; }; const getExpVariation = (id) => { let experiment = window._vwo_exp[id]; return experiment.combination_chosen || experiment.combination_selected; }; const defaultOptions = { id: [ 'VWO', getExpId(), getExpVariation(getExpId()) ].join('-'), tokenName: ("NA__MPR_DonationInterrupter:" + [ 'VWO', getExpId(), getExpVariation(getExpId()) ].join('-')), min: 10, max: 100, askAmount: (originalAmount) => { if (originalAmount > 500) // $500+ return false; // don't show if (originalAmount >= 400) // $400-$500 return 50; if (originalAmount >= 300) // $300-$399 return 40; if (originalAmount >= 200) // $200-$299 return 30; if (originalAmount >= 100) // $100-$199 return 15; if (originalAmount < 100) // $100- return 10; return false; }, askFrequency: (originalFrequency) => { return "monthly"; }, popupHTML: { headingHTML: (` `), bodyHTML: (` `), }, }; options = { ...defaultOptions, ...options }; console.log("Initializing donation interrupter."); return new Promise((resolve, reject) => { try { const dialogElement = document.createElement('dialog'); dialogElement.id = options.id; dialogElement.classList.add("popup", "donation-interrupter", "NA"); dialogElement.innerHTML = `
${options.popupHTML.headingHTML} ${options.popupHTML.bodyHTML}
`; document.body.appendChild(dialogElement); // // const api = new Object({ askAmount: options.askAmount, askFrequency: options.askFrequency, }); Object.defineProperties(api, { id: { value: options.id, writable: false, enumerable: true, configurable: false, }, tokenName: { value: options.tokenName, writable: false, enumerable: true, configurable: false, }, Dialog: { value: dialogElement, writable: false, enumerable: true, configurable: true, }, show: { value: function () { this.update(), this.Dialog.showModal(), vwoCustomEvent(`${this.id}:shown`); this.storedState.updateTokenProperty("lastShown", getCurrentDate()); this.hooks['onShow'].forEach((callback) => callback.call(this)); }, ...lockedProperty }, hide: { value: function () { this.Dialog.close(), this.hooks['onHide'].forEach((callback) => callback.call(this)); }, ...lockedProperty }, update: { value: function () { this.Dialog.dispatchEvent(new CustomEvent('update'), { bubbles: false }); }, ...lockedProperty } }); Object.defineProperty(api, 'storedState', { value: { storageApi: localStorage, getToken: (function () { const tokenName = this.tokenName, storageApi = this.storedState.storageApi; return JSON.parse(storageApi.getItem(tokenName)) || null; }).bind(api), setToken: (function (tokenValue) { const tokenName = this.tokenName, storageApi = this.storedState.storageApi; return storageApi.setItem(tokenName, JSON.stringify(tokenValue)); }).bind(api), updateTokenProperty: (function (tokenPropertyName, tokenPropertyValue) { let state = this.storedState.getToken() || {}; state[tokenPropertyName] = tokenPropertyValue; this.storedState.setToken(state); return (this.storedState.getToken() || {})[tokenPropertyName] || undefined; }).bind(api), } }); initHooks(api, ['onShow', 'onHide', 'onUpdate', 'onYes', 'onNo']); function handleDialogUpdate (event) { // update dynamic text in the dialog Array.from(this.Dialog.querySelectorAll('[data-value]')).forEach(async (el) => { const attributeValue = el.getAttribute('data-value'); const currentAmount = await window.NA.DonationForm.getAmount(), currentFrequency = await window.NA.DonationForm.getFrequency(); if (attributeValue.match("askAmount")) { el.textContent = this.askAmount(currentAmount); } else if (attributeValue.match("askFrequency")) { el.textContent = this.askFrequency(currentFrequency); } else if (attributeValue.match("originalAmount") || attributeValue.match("amount")) { el.textContent = currentAmount; } else if (attributeValue.match("originalFrequency") || attributeValue.match("frequency")) { el.textContent = currentFrequency; } }); this.hooks['onUpdate'].forEach((callback) => callback.call(this)); } api.Dialog.addEventListener('update', handleDialogUpdate.bind(api)); // const handleYes = (async function () { vwoCustomEvent(`${this.id}:DonationInterrupter:yes`); const currentAmount = await window.NA.DonationForm.getAmount(), currentFrequency = await window.NA.DonationForm.getFrequency(); const catchAsyncError = (error) => { console.error("An error occured:", error); debugger; this.hide(); }; window.NA.DonationForm.setFrequency(this.askFrequency(currentFrequency)).then((frequency) => { console.log("Updated frequency:", frequency); window.NA.DonationForm.setAmount(this.askAmount(currentAmount)).then((amount) => { console.log("Updated amount:", amount); setTimeout(() => { console.log("Submitting..."); try { window.NA.DonationForm.submit(); } catch (error) { console.error("Error when submitting."); } finally { this.hide(); } }, 100); }).catch(catchAsyncError); }).catch(catchAsyncError); this.storedState.updateTokenProperty("lastConverted", getCurrentDate()); }).bind(api); const handleNo = (function () { vwoCustomEvent(`${this.id}:DonationInterrupter:no`); setTimeout(() => { console.log("Submitting..."); try { window.NA.DonationForm.submit(); } catch (error) { console.error("Error when submitting."); } finally { this.hide(); } }, 100); this.storedState.updateTokenProperty("lastDismissed", getCurrentDate()); }).bind(api); const handleCancel = (function () { this.hide(); this.storedState.updateTokenProperty("lastDismissed", getCurrentDate()); }).bind(api); async function handleDialogButtonClick (event) { event.preventDefault(); if (event.target.hasAttribute('data-action')) { if (event.target.getAttribute('data-action').match("yes")) { await handleYes.call(this); this.hooks['onYes'].forEach((callback) => callback.call(this)); } if (event.target.getAttribute('data-action').match("no")) { await handleNo.call(this); this.hooks['onNo'].forEach((callback) => callback.call(this)); } } } Array.from(api.Dialog.querySelectorAll('.popup__footer button')).forEach((button) => button.addEventListener('click', handleDialogButtonClick.bind(api))); if (api.Dialog.querySelector('.btn-dismiss')) api.Dialog.querySelector('.btn-dismiss').onclick = handleCancel; window.NA.DonationForm.DonationInterrupter = api; async function shouldDonationInterrupterShow () { return new Promise(async (resolve, reject) => { const shouldSubmit = true, shouldNotSubmit = false; const shouldShow = () => { this.show(), resolve(shouldNotSubmit) }, shouldNotShow = () => resolve(shouldSubmit); try { const formIsValid = await window.NA.DonationForm.validate(); if (!formIsValid) return console.log("One or more donation form fields are invalid; donation interrupter will not be shown."), shouldNotShow(); const currentFrequency = await window.NA.DonationForm.getFrequency(), currentAmount = await window.NA.DonationForm.getAmount(), askFrequency = this.askFrequency(currentFrequency), askAmount = this.askAmount(currentAmount); if (!currentFrequency || askFrequency == currentFrequency) return console.log("Ask frequency returned false or invalid; donation interrupter will not be shown."), shouldNotShow(); if (askAmount == false || askAmount <= 0) return console.log("Ask amount returned false or invalid; donation interrupter will not be shown."), shouldNotShow(); } catch (error) { return console.error(error), shouldNotShow(); } try { /// Summary: shows when not seen before at all, or if seen and dismissed on a day that is not the current day (e.g. yesterday) const storedState = this.storedState.getToken(); if (!storedState || !storedState.hasOwnProperty("lastShown")) { // has not been seen before; first time return console.log("Donation interrupter not seen yet; donation interrupter will be shown."), shouldShow(); 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Dear reader,

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Political debates with family or friends can get heated. But what if there was a way to handle them better?

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You can learn how to have civil political conversations with our new e-book!

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Download our free e-book, Talking Sense: Have Hard Political Conversations, Better, and learn how to talk without the tension.

\n",DEAR_READER_CTA_TEXT="Get your free ebook »",DEAR_READER_CTA_LINK="https://cloud.connect.mpr.org/mprnews-cfw03-01-talking-sense?utm_campaign=cfw_talkingsense&utm_term=dearreader_co";!function(){const e=async function(r,t=100,n=1e4){t=Number.isInteger(t)&&t>0&&t<=100?t:parseInt(t);let a="Array";if("NaN"==t)return console.error("Invalid refresh interval:",t);Array.isArray(r)||"string"!=typeof r||(a="string",r=[r]);let o=e=>document.querySelector(e),i=e=>e.every(e=>!!o(e));return new Promise((l,s)=>{let c=(e,r=null)=>(r&&clearInterval(r),l("Array"==a||e.length>1?e.map(e=>o(e)):o(e[0]))),d=a=>{console.error(`${a.name}: ${a.message}`);return s(a,()=>e(r,t=100,n=1e4))};try{if(i(r))return c(r);let e=setInterval(()=>{if(i(r))return c(r,e)},1e3/t);setTimeout(()=>{try{if(!i(r)){clearInterval(e);let r=Error(`Failed to find matching elements within ${n}ms`);throw r.name="Timed Out",r}}catch(e){return d(e)}},n)}catch(e){return d(e)}})};e("article").then(e=>{e.insertAdjacentHTML("beforeend",`
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Dear reader,

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The trustworthy and factual news you find here at MPR News relies on the generosity of readers like you.\n

\n

Your donation ensures that our journalism remains available to all, connecting communities and facilitating better conversations for everyone.\n

\n

Will you make a gift today to help keep this trusted new source accessible to all?\n

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Minnesota researchers on the cusp of a diabetes cure

Lab work
A student in Meri Firpo's lab works on stem cell research at the University of Minnesota in Minneapolis, Minn. Dec. 5, 2011. Firpo leads the research on transforming skin cells into insulin-producing cells that could benefit diabetics. Firpo has been working on the stem cell research and gene expression analysis at the University of Minnesota for more than five years.
MPR Photo/Jeffrey Thompson

The cure for diabetes could come from cells from pigs being raised in germ-free pens in Western Wisconsin or from human skin cells in a lab on the University of Minnesota campus.

Those two experiments are part of a joint project launched one year ago by the University of Minnesota and the Mayo Clinic to defeat diabetes within the next 10 years. The effort is called the Decade of Discovery.

It's high-stakes research. Diabetes is a worldwide epidemic that is taking a huge toll in Minnesota. Health officials say one-third of all adults in Minnesota either have diabetes or are pre-diabetic, with blood glucose levels that are higher than normal.

ISLET CELLS FROM PIGS

With genetic characteristics that are remarkably similar to humans, pigs may hold the cure to diabetes. There is such promise in the animals that a nonprofit organization built a facility in western Wisconsin to supply pigs, or more specifically their insulin-producing cells, to University of Minnesota transplant researchers.

Insulin is a crucial hormone that helps us use energy from the food we eat. People with diabetes have lost their insulin cells or they don't work properly.

Islet cells from pigs
Pigs used for the production of islet cells are raised at the Diabetes Research and Wellness Foundation Islet Resource Facility, home of Spring Point Project, in western Wisconsin, Dec. 7, 2011. The islet cells, which have been produced by several generations of pigs at the barrier facility, are used by University of Minnesota researchers for transplantation into diabetic patients.
MPR Photo/Jeffrey Thompson

The pigs at the Spring Point Project -- placed in special pens where they are isolated from human germs -- could one day provide an unlimited supply of pancreatic, insulin-producing cells to all diabetic patients who need them.

"They are special because they are raised in this barrier facility, essentially in a bubble separated from the outside world," said Tom Spizzo, the project's executive director. "We can make sure that their health is extremely high so that we're minimizing the risk of transmission of any agents from the donated materials into the recipients."

In the more than four decades since the U of M performed the world's first pancreas transplant, only a few thousand severely ill diabetic patients have received donor organs or the clusters of insulin-producing cells that are called islets. There simply aren't enough donor pancreases to go around.

Nobody knows if pancreatic islet cells from pigs will effectively produce insulin in humans. The Food and Drug Administration has not yet given the university permission to proceed with human clinical trials. But U of M transplant surgeon Bernhard Hering said transplanted pig islets have worked in other animals he's tested.

"We have been able to show that we can reverse diabetes in monkeys for many, many months, for close to a year," Hering said. "Many people could not believe this and thought that is completely impossible."

At the earliest, the injecting of pig islet cells in humans could begin within a year. But it would likely take many more years to obtain FDA approval to market a new treatment.

ISLETS DEVELOPED FROM OTHER TYPES OF CELLS

Researchers at the U of M are working on other promising treatments as well.

Stem cell researcher Meri Firpo is studying whether human skin cells can be transformed into insulin-producing cells to treat diabetes. Her technique erases the cell's original purpose before giving it a new assignment.

Stem cell research
Undergraduate research assistants Upasana Arvindan and Erica Dobbs work in Meri Firpo's stem cell research lab at the University of Minnesota in Minneapolis, Minn. Dec. 5, 2011. Meri Firpo leads the research on transforming skin cells into insulin-producing cells that could benefit diabetics. Firpo has been working on the stem cell research and gene expression analysis at the University of Minnesota for more than five years.
MPR Photo/Jeffrey Thompson

"Right now all the cells in this plate are unspecified," Firpo said. "So they've been completely reprogrammed from the purpose they had as a skin cell into a cell that could become literally any cell type in the body."

The new cells Firpo creates closely resemble pancreatic islet cells. When she puts them into laboratory animals the cells secrete insulin. Firpo can't reveal much more about her research until it has been reviewed and published. But she said her discovery is also a big step forward in diabetes research.

"It seemed so improbable or even impossible," she said. "But we actually are making the progress that we expected to. And we fully intend to do what we say we will do. We will cure diabetes."

Like Dr. Hering, Firpo also has to prove first that her cells could be used safely in humans.

ARTIFICIAL PANCREAS

While Decade of Discovery scientists search for a cure for diabetes, other researchers are focused on perfecting the devices diabetics already use to manage their disease.

One technology that could be available soon is an artificial pancreas that more precisely regulates blood sugar. It's also referred to as a closed-loop system.

Research subject
Melissa Mulder, 32, of Plainview, Minn., took part in an experiment at the Mayo Clinic that measured her activity over a period of five days, to better determine how physical activity affects blood sugar levels. Mulder has had type diabetes for 17 years.
Photo by Alex Kolyer for MPR

Current methods of measuring blood sugar are not very precise, since glucose monitor readings are about 20 minutes old by the time a patient sees them and programs that information into their insulin pump. By using an artificial pancreas that receives information from an activity monitor which measures how many calories a person burns, researchers aim to make such devices communicate more precisely with each other.

Research groups around the world have been experimenting with "closing the loop" between insulin pumps and glucose monitors used by diabetics. Researchers think they can do so in much the same way pacemakers regulate hearts.

Dr. Yogish Kudva, a Mayo Clinic endocrinologist, described a prototype of an artificial pancreas as a "continuous glucose sensor and transmitter."

A couple of the devices in his laboratory are as small as a pager. The computer that links them together is about the size of a smartphone.

"Our studies are essentially to make the software better and to individualize the software for each patient," Kudva said.

To study the effectiveness of the devices, Mayo researchers are trying to figure out how many calories a person really burns in a day, because activity determines the amount of insulin a person needs. In order for an artificial pancreas to deliver insulin as perfectly as the human body, the device needs to be programmed accurately to account for even the tiniest of movements.

In one test, 32-year-old diabetic Melissa Mulder, of Plainview, Minn., took part in an experiment that measured her activity over a period of five days.

Clothing fitted with sensors
Dr. James Levine is a researcher at Mayo Clinic focusing on movement and how it affects metabolism. Levine has developed a set of undergarments fitted with sensors that can record each movement made by the person wearing it. The information collected can then be used to learn how a person burns calories and how it affects the sugar levels in the body.
Photo by Alex Kolyer for MPR

"Twenty minutes where I sat, 20 minutes where I walked on the treadmill, 20 minutes where I sat, just back and forth, back and forth," Mulder said. "It was the most structured study that I'd ever done."

Mulder, who has had diabetes for 17 years, said she gets very upset with herself when her blood sugar levels fluctuate because she knows she's damaging her body. She thinks a machine could do a better job.

"I wouldn't have to worry about those long-term complications so much, keeping my numbers so tight, trying to do it on my own," she said. "We always hear about the long-term complications of diabetes. And it's inevitable, no matter how well of a job that I'm doing."

The system could revolutionize diabetes care, said Dr. James Levine, a member of the team working on Mayo's artificial pancreas. But it's not a cure.

"I don't think any of us believe that these machine-based solutions and equations will ever be perfect," Levine said. "What we're trying to do is to close the gap between substantial imperfection and a better solution for real patients living in the real world."

Mayo has yet to test its artificial pancreas system on patients. But researchers in Europe have tested a similar system on two diabetics.

Researchers in France and Italy each connected a patient to the devices for 24 hours while a team of doctors and computer engineers monitored their health. The patients, who each ate a meal at a restaurant and then spent a night in a hotel where they were monitored by research teams, were able to attain near-normal glucose levels for one night.

That marked a significant advance because, for the first time, patients were able to control their diabetes using an artificial pancreas in a real-life setting.

Kudva hopes that within two years he will be able to test Mayo's artificial pancreas on the first human patients in the United States.

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